JEVAX® Japanese encephalitis vaccine

JEVAX is a result of technology transfer from the BIKEN Institute, Osaka University, Japan. It is an inactivated purified vaccine derived from mouse-brain tissue infected with the Japanese encephalitis virus (Nakayama strain). The vaccine production involves harvesting mouse brains before the onset of encephalitis symptoms, triturating them in a buffered solution, and then centrifuging the mixture. The obtained supernatants are treated with protamine sulfate, formaldehyde-inactivated, and purified through ultracentrifugation.

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