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Currently, we produce four types of vaccines: Hepatitis A Vaccine (HAVAX®), Recombinant Hepatitis B Vaccine (Gene-HBvax), Japanese Encephalitis Vaccine (JEVAX®), and Oral Cholera Vaccine (mORCVAX).
MANUFACTURED PRODUCTS
HAVAX®Hepatitis A Vaccine
Hepatitis A virus (HM 175 hepatitis A strain) is propagated on primary monkey kidney cell cultures to produce this vaccine. Aer purification from cell lysates, the HAV preparation is formaldehyde-inactivated. The vaccine is adjuvanted by adsorption to aluminum hydroxide. HAVAX is used for the prevention of Hepatitis A virus infection.
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MANUFACTURED PRODUCTS
Gene-HBvaxRecombinant hepatitis B vaccine
Gene-HBvax is a recombinant Hepatitis B vaccine used to prevent Hepatitis B virus infection. This vaccine utilizes the surface antigen of the Hepatitis B virus (HBV) obtained through culturing genetically engineered Hansenula polymorpha yeast cells containing the HBV surface antigen gene. The Hepatitis B surface antigen (HBsAg) is purified through various chemical processes, including ultracentrifugation, column chromatography, and formaldehyde treatment.
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MANUFACTURED PRODUCTS
JEVAX®Japanese encephalitis vaccine
JEVAX is a result of technology transfer from the BIKEN Institute, Osaka University, Japan. It is an inactivated purified vaccine derived from mouse-brain tissue infected with the Japanese encephalitis virus (Nakayama strain). The vaccine production involves harvesting mouse brains before the onset of encephalitis symptoms, triturating them in a buffered solution, and then centrifuging the mixture. The obtained supernatants are treated with protamine sulfate, formaldehyde-inactivated, and purified through ultracentrifugation.
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MANUFACTURED PRODUCTS
mORCVAXOral cholera vaccine
The vaccine is a liquid formulation of oral Cholera vaccine containing O1 (consisting of V.Cholerae classical type and Eltor) and O139 of Vibrio cholerae inactivated with either heat or formaldehyde. The manufacturing process consists of following steps: culture in appropriate medium, inactivate by formaldehyde or heat, concentrate by centrifugation or filtration, remove cholera toxin. The formulation of final bulk is calculated by Lipopolysaccharide (LPS) content to ensure concentration of the antigens required to stimulate immunogenicity for the prevention of cholera disease.
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